It replaced an earlier station named Ditton Mill which was inconveniently located off the then new main line some 230 yards (210 m) to the east.

On 17 September 1912, 15 people were killed when the 17:30 train from Chester derailed while crossing from the fast to the slow line at speed.

By the late 1980s even this service had begun to omit Ditton from its schedule and dwindling passenger numbers eventually led to its closure.

[12] As of 2023 the platforms survive and can easily be seen from passing trains, and the site of the station buildings is visible from the road, marked by the more modern brickwork of the bridge parapet.

Halton Borough Council has protected the site of the station as well as the Halton Curve from development prejudicial to their reuse as part of the rail network; the council notes that "there is an opportunity for the re-opening of this station, particularly with the possible increase in patronage from major industrial, commercial and housing developments in the area.