Khosla started her career as a model and appeared in various music videos notably "Zid Na Karo Ye Dil Ka Mamla Hai" by Roop Johri and Kunal Ganjawala and Falguni Pathak's "Aiyyo Rama".

[4] She also appeared with Salman Khan in the music video "Zid Na Karo Ye Dil Ka Mamla Hai", sung by Roop Johri and Kunal Ganjawala.

[7] In the same year, she made her Hindi cinema debut with the film Ab Tumhare Hawale Watan Saathiyo, in which she portrayed Shweta, the wife of Major Rajeev Singh played by Akshay Kumar.

The film received negative reviews; however, the Times of India noted, "Divya Khosla is pleasant and has a fairly prominent part to play in this otherwise male-dominated movie.

[24] In 2020, Divya featured in the video song "Teri Aankhon Mein" with Pearl V. Puri, sung by Darshan Raval and Neha Kakkar.

[26] During the trailer launch of the film, Khosla revealed that the role is based on her, and recalled the memories of her when the director cast her after seeing her audition in Delhi when she was just 14.

"[30] Her next film action thriller Savi (2024), directed by Abhinay Deo, focuses on the story of a woman who fights to save her family and others by standing up against the government and administration,[31] it also starred Anil Kapoor and Harshvardhan Rane.

[34] Titas Chowdhury of News18 wrote that "the film marks a revelation of sorts as it sees Divya hitting all the emotional notes right, a feat we haven't had the opportunity to witness in the past.

She skillfully embodies a complex character, showcasing palpable depth in her portrayal of Savi's vulnerability and strength, creating a unique blend of fragility and fearlessness.

"[35] Abhishek Srivastava of Times of India stated "Divya Khossla takes on the challenging role of Savi, and her hard work is evident in her performance.