Djibouti–Eritrea relations refers to the current and historical relationship between neighboring states Djibouti and Eritrea.

While Guelleh had close ties with Ethiopia's ruling Ethiopian People's Revolutionary Democratic Front (EPRDF), he has tried to maintain an even hand, developing relations with Eritrea.

On June 10, 2008 fighting broke out in the Ras Doumeira region between Djibouti and Eritrea.

It resulted in Djiboutian victory and the eventual withdrawal of Eritrean forces from the border areas and the creation of a buffer zone between the two countries.

Shortly after, Djibouti accused Eritrea of reoccupying the mainland hill and Doumeira Island.