Mykhaylenko won the bronze medal in the FIFA World Youth Championship 1991 with the Soviet Union U20 national team at the age of 17.

He was in the squad of the Ukraine U21 national team which finished second in 1996 UEFA European Under-21 Football Championship Qualifying round group 4.

He made his senior debut with Ukraine against Israel, 27 April 1993.

[1] Upon retiring from football, Mykhaylenko became a commentator for Ukrainian Premier League football matches, debuting on 25 July 2009 in the home match of Dnipro Dnipropetrovsk - Metalist Kharkiv, in which Dnipro Dnipropetrovsk won 2–0.

On 30 June 2016, Mykhaylenko was appointed acting head coach of Dnipro Dnipropetrovsk's first team, and later moved to the newly created Dnipro-1 together with the coaching staff.