Marcos, having absolute authority using dictatorial powers, grabbed large swaths of lands from nearby town to create the present borders of Doña Remedios Trinidad, despite opposition.

Historians have noted that Marcos named the towns to honor a person without much significant historical value, with only family ties as actual reason.

The municipality covers seven barangays: Pulong Sampaloc and Camachile from Angat; Bayabas and Kabayunan from Norzagaray; and Talbac, Camachin and Kalawakan from San Miguel.

It lies on the southern edge of the Sierra Madre mountain range, and partially embraces three major conservation areas: the Angat Watershed Forest Reserve, Biak-na-Bato National Park, and Doña Remedios–General Tinio Watershed Forest Reserve, comprising 327.3 km2 (126.4 sq mi) of alienable and disposable public land.

On December 12, 2007, the Province of Bulacan and the Metropolitan Waterworks and Sewerage System (MWSS) signed an agreement for the development of an P11-billion bulk water supply project.