Over his major league career, Amole compiled a record of 4–10 with a 4.75 earned run average (ERA) and 30 strikeouts in 18 games, 12 starts.

In 1896, Amole began his professional baseball career with the Class-A Wilmington Peaches of the Atlantic League.

[1] Amole threw the pitch to Honus Wagner who made contact with the explosive, setting off a large spark, causing the crowd to erupt in anger and the already unpopular game was ended immediately.

[2][3] During that season, Amole compiled a record of 22–24 with a 2.54 earned run average (ERA) in 55 games, 47 starts.

[7] In December 1897, the Baltimore Orioles traded Amole with Jack Doyle and Heinie Reitz to the Washington Senators in exchange for Doc McJames, Dan McGann and Gene DeMontreville.

On Opening Day in 1900, Amole pitched a no-hitter, making it the first one thrown in American League history.

Amole was found dead on the floor of his room at a boarding house in Wilmington, Delaware on March 9, 1912.