The area is characterized by its predominantly working-class background, with many of its inhabitants pertaining to diverse immigrant communities.

Former Argentina national football team captain Javier Zanetti grew up in Dock Sud.

[2] The oldest and most important neighborhood in Dock Sud is Isla Maciel, which is home to Club Atlético San Telmo.

The Nicolás Avellaneda housing complex, started in 1973 by President Héctor Cámpora, is the second most important, and is located on the eastern side of the Buenos Aires-La Plata Freeway.

Dock Sud, a predominantly working-class district, has in recent decades been afflicted with some of the nation's highest crime rates.