Doctor Coss is both a city and a municipality in Nuevo León, Mexico.
The first settlement, Paso del Zacate, was formed around 1745 with families from Los Aldamas, Nuevo León and General Bravo.
Almost a century later Paso del Zacate was declared a villa by the state congress and finally, on October 7, 1882, the municipality of Doctor Coss was formed with the unification of Paso del Zacate, Zacate, Soledad, El Ebanito, La Lajilla, Los Chorros, Tecomate, Lucero, Las Mujeres and Gachupines.
The municipality has an area of 664.6 km2 and is bordered by the state of Tamaulipas to the north, General Bravo to the east and Los Aldama and China to the west.
It is located 134 meters above sea level (which makes it the highest municipality in the state) and is crossed by the San Juan river.