The game is set in late 19th-century Paris, and follows the eponymous protagonist, archaeologist Doctor Lautrec, on his quest for a hidden treasure of the Bourbon dynasty.

The protagonist of the game, the eccentric and mystery-solving archaeologist Doctor Jean-Pierre Lautrec, is a lecturer at the city's Museum of Natural History.

[4][5][6][7] Doctor Lautrec and the Forgotten Knights was designed, written, directed and produced by Zone of the Enders director Noriaki Okamura.

The UK Official Nintendo Magazine stated that the game had a lot of work put into it, but in general, slowly falls into repetition, with them giving it score of 69%.

They also noted its overt similarities to the Professor Layton series, and often referred to the game as a flagrant rip-off of the aforementioned franchise that is clearly intended to "cash-in" on its success.