Dolcenera participated again in the Sanremo Music Festival in 2006—when she sang the hit single "Com'è straordinaria la vita", included in the album Il popolo dei sogni—and in 2009, singing "Il mio amore unico", from her fourth studio set Dolcenera nel paese delle meraviglie, the first one released by a major label, Sony Music.

During the same year, she appeared on the Italian version of Professor Green's single "Read All About It (Tutto quello che devi sapere)", which was also included in the 2012 edition of Evoluzione della specie, released after Dolcenera's participation in the Sanremo Music Festival 2012 with "Ci vediamo a casa".

[7] In the early 2000s she met through a web chat the Italian musician and record producer Lucio Fabbri, former member of the progressive rock band Premiata Forneria Marconi.

[23] In 2006 Dolcenera participated in the 56th Sanremo Music Festival singing "Com'è straordinaria la vita",[24] the lead single from her second album, titled Il popolo dei sogni.

[26][27] In 2009 she signed a recording contract with Sony Music and she published her fourth studio album, titled Dolcenera nel paese delle meraviglie.

[28] The first single from the album, "Il mio amore unico", was performed during the 59th Sanremo Music Festival, competing in the "Artists" section,[29] but it failed to reach the final.

[33] In April 2009, she recorded the song "Domani 21/04.09" with the charity supergroup Artisti Uniti per l'Abruzzo, formed to raise money for the population struck by the earthquake in L'Aquila.

[44] She also featured on the Italian version of Professor Green's song "Read All About It (Tutto quello che devi sapere)", included in British rapper's second studio album, At Your Inconvenience, and released as a digital single on 9 December 2011.

[45] In February 2012, Dolcenera participated in the 62nd Sanremo Music Festival, placing sixth[46] with the song "Ci vediamo a casa",[47] written for the soundtrack of Maurizio Ponzi's film with the same title.

[52] In 2008 she starred alongside Cristiana Capotondi, Primo Reggiani and Ludovico Fremont in the movie Scrivilo sui muri, directed by Giancarlo Scarchilli.