[4][5] Domani was first published on 12 September 2020 and has since been edited by Stefano Feltri, former deputy editor of Il Fatto Quotidiano.

According to Feltri, one month after its establishment, the newspapers was selling an average of 14,000 print copies per day and had 7,000+ digital subscribers.

[7] At the end of October 2020, Luigi Zanda resigned from chairman of the publishing society because of conflict of interest with his role of senator of the Democratic Party (he had earlier resigned from party's treasurer in order to take the post),[8][9] especially as the newspaper started to be very critical of the Second Conte Cabinet, of which the Democrats were junior partners.

[11] In March 2023 Claudio Durigon, Undersecretary at the Ministry of Labour and Social Policies of the Meloni government filed a criminal complaint for defamation against Domani, following an article by journalists Giovanni Tizian and Nello Trocchia.

Soon after that, the newspaper's headquarters were raided by the Carabinieri, who seized print copies of such article under the order of the Office of Prosecutors of Rome.