Domenico Gilardi (Russian: Доменико Жилярди; 1785–1845) was a Swiss Italian architect who worked primarily in Moscow, Russia in Neoclassicist style.

Domenico returned to Russia in June 1810, and in January 1811 joined his father, who was the architect of the enormous Moscow Orphanage (Russian: Воспитательный дом, Foundling House).

In a very short time, Gilardi concentrated the efforts to restore the four largest public buildings in the city, with the aid of Afanasy Grigoriev, a recently emancipated serf architect.

Gilardi's style goes back to the Milan variety of Empire Classicism, Luigi Cagnola and in particular Antonio Antolini's Bonaparte Forum.

Gilardi's architectural talent is disputed, but his success in construction management and ability to lead concurrent major projects is unquestionable.

His first work in new construction was the Board of Trustees building, a new block on the Orphanage lot (Solyanka Street, now Academy of Medical Science).