She was daughter and heiress of the 5th Prince, and as such was a Grandee of Spain 1st Class, 5th Duchess of Acerenza, 8th Marchioness of Galatone, 5th Countess of Copertino, 7th Baroness of Badolato, Signore di Veglie, Leverano, San Cosimo etc.

He was subsequently consecrated Bishop on 3 March 1782 in Rome, at the church of San Silvestro al Monte, by Cardinal Innocenzo Conti, Secretary of the Chancery of Apostolic Briefs, who was assisted in the ceremony by Girolamo Volpi, Titular Archbishop of Neocesarea, and by François de Pierre de Bernis, Titular Bishop of Apollonia, Vicar General of Albi.

He was created a Cardinal Priest in the consistory of 9 August 1802, and received the red biretta on 5 December 1802, in the chapel of the Seminary of Palermo.

He was Knighted in the Illustrious Royal Order of St. Januarius (L'Insigne Reale Ordine di San Gennaro).

Cardinal Domenico died of gout before receiving the red hat and title of his cardinalate, and was buried in the church of the Congregation of Clerks Regular of the Divine Providence (The Theatines), in Palermo.