(3 August 1852 – 5 March 1918) was an Italian Cardinal of the Roman Catholic Church who served in various pastoral, diplomatic, and curial posts, and was elevated to the cardinalate in 1914.
His maternal grandfather, Giovanni Di Pietro, was a consistorial lawyer who, after becoming a widower, was ordained and named auditor of the Roman Rota by Pope Gregory XVI.
After being named prior of the St Scholastica monastery, Serafini became the general procurator of his religious order in Rome in 1892.
He received his episcopal consecration on the following 6 May from Cardinal Serafino Vannutelli, with Archbishops Casimiro Gennari and Tommaso Granello, OP serving as co-consecrators.
Serafini was later named Apostolic Delegate to Mexico on 4 January 1904, assessor of the Supreme Congregation of the Holy Office on 30 November 1911 and Titular Bishop of Seleucia Pieria on 2 March 1912.