On 19 July 1482 he was appointed Apostolic Administrator of the diocese of Geneva, during the Sede vacante following the death of Joannes Ludovicus de Sabaudia.

[3] In 1483, he laid the cornerstone for the new cathedral of S. Margherita in Montefiascone, and in his Last Will and Testament in 1501 he left money to continue the work, which had barely reached the level of the main floor of the church at the time of his death.

[4] After Sixtus' death in 1484, he went to Rome to participate in the papal conclave, which elected Pope Innocent VIII.

In Piedmont, he funded the Collegiate church of Saluzzo and the rebuilding of the Turin Cathedral, as well as a new castle in Vinovo to serve as his residence.

In Piazza Scossacavalli, in the Borgo rione of Rome, he commissioned Pinturicchio the decoration (including the Semi-Gods Ceiling) of the Palazzo bearing his name, whose construction he had started in 1480, perhaps under design by Baccio Pontelli.