Domeyrot (French pronunciation: [dɔmeʁo]; Occitan: Domeiròt) is a commune in the Creuse department in the Nouvelle-Aquitaine region in central France.

A farming area comprising the village and several hamlets, situated some 12 miles (19 km) northeast of Guéret at the junction of the D40, D13 and the D66 roads.

The small river Verraux, a tributary of the Petite Creuse, forms the commune's southern and western boundaries.

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