Born in Farim on October 20, 1963, Domingos Simões Pereira is the son of a farmer, a small landowner forced to abandon the property due to the beginning of the war of independence.

In 1974, he joined the first groups of students who, at National Lyceum Kwame N'Krumah, under the teaching of names like Atchutchi Ferreira and Helder Proença, studied without the tutelage of the colonial regime.

In 1990 he entered the first cycle of formation of the PAIGC aiming at the democratic opening, and in this period his proximity to the top management of the party is worth the opportunity to continue his studies.

During the four-year term, he bet on the organization's affirmation at the international level and with civil society; developed concrete partnership and cooperation actions in the most varied domains; he did not neglect the importance of Portuguese and the culture that unites and diversifies the identity of the peoples of the CPLP.

In February 2014, at the 8th PAIGC Ordinary Congress, in the city of Cacheu, he was elected to the leadership of the party, and; between 3 July 2014 and 20 August 2015, he served as Prime Minister of Guinea-Bissau.