Dominic "Dom" Reilly is a fictional character from the British Channel 4 soap opera Hollyoaks, played by John Pickard.

Tina's sisters Michaela (Hollie-Jay Bowes) and Carmel McQueen (Gemma Merna) overhear Dom speaking lovingly on a phone to "Cathy", a character from he and Tina's favourite book, who they assume to be Kathy Barnes (Sarah Jane Buckley) and accuse Dom of having an affair.

Dom and Tina reconcile when he finds her fatally wounded due to an explosion caused by Niall Rafferty (Barry Sloane).

Dom becomes romantically involved with pole dancer Loretta Jones (Melissa Walton), however their relationship ends after he makes her choose between him and her career.

At first Dom turns to Warren Fox (Jamie Lomas) for a loan of 10,000 pounds, however Warren instructs Dom to get a set of matches and burn the Il Gnosh down and on the same night, Il Gnosh is set on fire by an unseen arsonist, which causes the deaths of Steph Roach (Carley Stenson) and Malachy Fisher (Glen Wallace).

Ste Hay (Kieron Richardson) tells Dom he believes Brendan Brady (Emmett J. Scanlan) set the fire.

Tony then confides in Dom, who again admits the truth, revealing he set the fire to destroy a laptop which Bart McQueen (Jonny Clarke) had told him had pictures of Amber on it.