His life was the basis of the film My Brother…Nikhil (directed by Onir) and the novel The Lost Flamingoes of Bombay by Siddharth Dhanvant Shanghvi.
Upon learning he was infected, authorities forcibly quarantined him, keeping him isolated in a tuberculosis ward for 64 days.
Together with his friend Isabel de Santa Rita Vas, he founded the HIV/AIDS non-governmental organization Positive People in April 1992.
As a young man he was one of the first actors to participate in the Mustard Seed Art Company, Goa's most notable English-language theater, founded by Isabel de Santa Rita Vas.
She and the legal team led by Anand Grover argued that Section 53 of the Goa Public Health Act—a section added in the 1987 amendment to specify restrictions and provisions regarding AIDS—violated articles 14, 19, 21, and 226 of the Indian Constitution, as well as the government-endorsed World Health Organization guidelines.
Though the case dragged on for months, the court issued an interim order in mid-April releasing Dominic from the sanatorium and confining him instead to house arrest at his home in Parra.
[3] After being released from house arrest, Dominic was fired from his job at the World Wildlife Fund, and went to work for Norma Alvares, a woman who had contributed to his court case and had much experience with NGOs.