Its 64-acre (260,000 m2) suburban campus in Orangeburg is 17 miles (27 km) from New York City in Rockland County.

[6] The university is a member of the Division II ranks of the National Collegiate Athletic Association (NCAA), primarily competing in the Central Atlantic Collegiate Conference (CACC) for most of its sports since the 1982–83 academic year.

They are also a member of the Eastern College Athletic Conference (ECAC) for some sports.

[citation needed] Dominican competes in 17 intercollegiate varsity sports: Men's sports include baseball, basketball, cross country, golf, lacrosse, soccer, tennis and track & field; while women's sports include basketball, cross country, golf, lacrosse, soccer, softball, tennis, track & field and volleyball.

[citation needed] The Chargers have a cross-campus rivalry with the nearby St. Thomas Aquinas College Spartans since the two colleges are located a mile from each other.