He is a member and founder of the group of comedians Les Nuls alongside Alain Chabat, Chantal Lauby and Bruno Carette.

Thus he meets Canal+ first weatherman, Alain Chabat, with whom he would form the group of comedians Les Nuls alongside Chantal Lauby and Bruno Carette in 1986.

After Les Nuls split, Dominique Farrugia starts a film career as a director with Delphine 1, Yvan 0 and Trafic d'influence.

In 1997 he founded the cable and satellite TV channel Comédie !, discovering new comic talents such as Les Robins des Bois, Franck Dubosc, Titoff, Kad & Olivier and Jonathan Lambert.

In 2010, he co-directed with Arnaud Lemort the film L'amour c'est mieux à deux (1,250,000 entries in France, more profitable movie of 2010, with its particular stage of Clovis Cornillac, Virginia Efira and Manu Payet.