Dominique-Marie Varlet (15 March 1678 in Paris – 14 May 1742 in Rijswijk) was a French prelate and missionary of the Catholic Church who served as vicar general of the Diocese of Quebec.

He was chosen to travel to the French territory of Louisiana and revive the Sainte-Famille mission for the Tamaroa tribe in Cahokia (now East St Louis, Illinois), which had been without a priest since Father Marc Bergier's death in 1707.

[8] In January 1713, Varlet sailed from Port-Louis (in the department of Morbihan) and arrived on June 6 at Mobile Bay, Alabama, where he suffered from dysentery and spent time recovering with fellow religious Albert Davion and François Le Maire.

[10] In 1715, Varlet joined an expedition organized by Louisiana governor Antoine de la Mothe Cadillac and finally reached the mission of Sainte-Famille in Cahokia.

On May 10, 1718, Goulven Calvarin, Dominique-Antoine-René Thaumur de La Source, and Jean-Paul Mercier departed for Cahokia, but Varlet would never return there.

Varlet left Paris on March 18, 1719 without signing his consent to the papal bull Unigenitus Dei Filius, which had previously condemned 101 Jansenist propositions by Pasquier Quesnel.

[17] Varlet insisted that, coming from Canada, he knew nothing of Unigenitus, that he was ordered to travel as privately as possible, and that the Chapter of Utrecht, which had jurisdiction during the vacancy of the see, had invited him to celebrate the sacrament of confirmation there.

[19] Obliged to retrace his steps to Paris to lift the interdict, Varlet returned to Europe, stopping through Amsterdam where he sympathized with the plight of the Dutch Jansenists.

[20] After Pope Clement XI, the author of Unigenitus, died in 1721, Varlet returned to Paris, where he stayed with Bishop Charles de Caylus of the Diocese of Auxerre.

[22] In Rome, François de Montigny, procurator of the Société des Missions Étrangères, attempted to regularize Varlet's situation.

On September 30, 1725, in the Church of St. James and St. Augustine in The Hague, Varlet consecrated Cornelius Johannes Barchman Wuytiers as the eighth Archbishop of Utrecht.