He was a co-founder and is a senior advisor of the Paris-based Institut Français des Relations Internationales (IFRI), Pierre Keller Visiting Professor at Harvard University, and the chairholder for Geopolitics at the College of Europe, the oldest educational institution in European affairs, in Natolin.

Moïsi regularly contributes op-ed articles and essays to the Financial Times, Foreign Affairs, the Project Syndicate as well as Die Welt and Der Standard.

After the fall of the Berlin Wall in 1989, he aroused attention as one of the first French commentators to welcome the conceivable end of Germany's division as an opportunity for Europe.

[5] Many years later Moïsi explained his position by pointing to his father whose fate as an Auschwitz survivor had made him "fall in love with Europe".

[6] During the 1990s Timothy Garton Ash, Michael Mertes and Dominique Moïsi wrote several "trilateral" (British-German-French) pleas in favour of a combined eastward enlargement and institutional modernisation of the EU.