Cardinals, bishops and priests who visit the Pope in Rome or who participate in the various apostolic works of the Holy See also stay at the Domus.

In 1573, the palazzo on the site that the present Domus occupies became the seat of the Germanic College, founded by Saint Ignatius of Loyola (1491-1556) and approved by Pope Julius III in 1552.

In 1580, Pope Gregory XIII united the college with the Hungarian Institute, which he had founded, thus establishing the Collegium Germanicum et Hungaricum, which was entrusted to the care of the Jesuits.

[2] In July 1773 the Society of Jesus was suppressed, and the German College was subsequently placed under the care of diocesan clergy until 1789, at which time it was closed and transferred to Ferrara (Emilia-Romagna).

It was not until 1976 that the Domus Internationalis "Paulus VI", under the name "Casa Internazionale del Clero", was established, but a marker at the entrance to Room 426 indicates it as the one preferred by Angelo Roncalli, the future Pope John XXIII, on his visits to Rome.

Pope Francis returned in person on the day after his election in order to pay the bill for his stay as Cardinal Jorge Bergoglio before the conclave of March 2013 and to thank the staff.