The film was the fifth and last screen appearance of Judy Ann Santos and Piolo Pascual together (after Esperanza: The Movie, Kahit Isang Saglit, Bakit 'Di Totohanin and Till There Was You) prior to the premiering of Sa Piling Mo next month as well as the non-official entry for the 31st Metro Manila Film Festival almost 3 weeks later.

The Cinema Evaluation Board (CEB) gave Don't Give Up on Us a B rating,[2] which made it eligible for a 65% tax rebate on its earnings in the Philippines.

The Movie and Television Review and Classification Board (MTRCB) gave Don't Give Up on Us a PG-13 rating [3] which required parental guidance for viewers under thirteen years of age.

With a cassette tape left behind by Sabina as her only lead, Abby vows to find her best friend and bring her back in time for the wedding.

There she meets Vince (Piolo Pascual) and his younger brother Marco, a folk singer in a local pub whose voice she heard in Sabina's tape.