It was written by band members will.i.am and Fergie with Printz Board, George Pajon, Jr. and Full Force; will.i.am also produced and engineered the song.

It features compositional samples of songs derived from two Bollywood films of the 1970s, Apradh (1972) and Don (1978), as well as interpolations of Lisa Lisa and Cult Jam's 1985 single "I Wonder If I Take You Home" and Gucci Crew II's 1988 single "Sally (That Girl)", hence earning Kalyanji–Anandji, Indeewar and Full Force songwriting credits.

[2] The song contains samples of several songs: "I Wonder If I Take You Home", written and composed by Full Force, and "Ae Naujawan Sab Kuchh Yahan" and "Yeh Mera Dil Pyaar Ka Diwana", both recorded by Asha Bhosle, composed by Kalyanji Anandji, and with lyrics written by Indeewar.

[2] Black Eyed Peas member will.i.am, in addition to co-writing the song, produced the track on his own while working with Neil Tucker and Tal Herzberg on engineering it.

"[5] Jason King of The Village Voice called the song a "sassy gender duel" between will.i.am and Fergie, while commenting that it is reminiscent of "Shut Up".

[6] Nicholas Taylor of PopMatters called "Don't Phunk with My Heart" a "standout" in regard to "complex and engaging hip-hop music, a mix of rap, soul, jazz, and funk that will constantly surprise and delight."

However, he stated that "Pump It" would have been a better choice for the first single, writing that it "continually impresses and grooves and better melds raps with beats", while noting "Don't Phunk with My Heart" to get repetitive and clunky.

[10] Azeem Ahmad of musicOMH predicted the album Monkey Business to be a success if "Don't Phunk with My Heart" was an indication of its sound.

[12] Kelefa Sanneh of The New York Times called it "a much more wholesome hip-hop hit", comparing it to Ying Yang Twins' 2005 single "Wait (The Whisper Song)".

[13] In the United States, "Don't Phunk with My Heart" entered the Billboard Hot 100 at number ninety-seven following its release.

[19] The song sold over 500,000 digital copies in the United States, earning a gold certification by the Recording Industry Association of America (RIAA).

[20] In the United Kingdom, "Don't Phunk with My Heart" entered and debuted at number three on the UK Singles Chart on May 22, 2005 (for the week ending May 28, 2005).

[25] The song has shipped over 70,000 copies in Australia, earning a platinum certification by the Australian Recording Industry Association (ARIA).

[30] Across the rest of Europe, "Don't Phunk with My Heart" achieved top-five positions in Austria, Denmark, Finland, Flanders, Italy, the Netherlands, Spain, and Switzerland and reached the top ten in France, Germany, Sweden, and Wallonia.

will.i.am, apl.de.ap and Taboo attempt to win the heart of Fergie, a beautiful girl, by being chosen to go on a date with her by spinning a wheel to decide where they will go, then being teleported to the site.