[1] Man and Superman opened at the Royal Court Theatre in London on 21 May 1905 as a four-act play produced by the Stage Society, and then by John Eugene Vedrenne and Harley Granville-Barker on 23 May, without Act III ("Don Juan in Hell").

In 1974–1975, Kurt Kasznar, Myrna Loy, Edward Mulhare and Ricardo Montalbán toured nationwide in John Houseman's reprise of the production, playing 158 cities in six months.

[5][11][12] As Shaw notes in his "Epistle Dedicatory" (dedication to theatre critic Arthur Bingham Walkley) he wrote the play as "a pretext for a propaganda of our own views of life".

[5] Sally Peters Vogt proposes: "Thematically, the fluid Don Juan myth becomes a favorable milieu for Creative Evolution", and that "the legend ... becomes in Man and Superman the vehicle through which Shaw communicates his cosmic philosophy".

[20] In 1981, London's National Theatre staged a production, with the "Don Juan in Hell" act included, directed by Christopher Morahan and starring Daniel Massey as Jack Tanner and Penelope Wilton as Ann Whitefield.

[23] In 1990, South Coast Repertory in Costa Mesa, California staged a production, with the "Don Juan in Hell" act included, directed by Martin Benson and starring John de Lancie as Jack Tanner and his wife Marnie Mosiman as Ann Whitefield.

[24] In 1996, to celebrate BBC Radio 3's 50th Anniversary, Sir Peter Hall directed an audio production with Ralph Fiennes as Jack Tanner, Judi Dench as Mrs. Whitefield, John Wood as Mendoza, Juliet Stevenson as Ann Whitefield, Nicholas Le Prevost as Octavius Robinson and Jack Davenport as Hector Malone.

In 2012, the Irish Repertory Theatre and Gingold Theatrical Group presented a revival directed and adapted by David Staller and starring Max Gordon Moore as Jack Tanner.

[25] In 2015, London's National Theatre staged a production, with the "Don Juan in Hell" act included, directed by Simon Godwin and starring Ralph Fiennes as Jack Tanner and Indira Varma as Ann Whitefield.

[26] In 2019, Canada's Shaw Festival staged the full production with Martha Burns as Mendoza/The Devil, Gray Powell as Jack Tanner and Sara Topham as Ann.