Don Mot Daeng (Thai: ดอนมดแดง, pronounced [dɔ̄ːn mót dɛ̄ːŋ]; Northeastern Thai: ดอนมดแดง, pronounced [dɔ̄ːn mòt dɛ̄ːŋ]) is a district (amphoe) in the central part of Ubon Ratchathani province, northeastern Thailand.

The district is named after the island Don Mot Daeng in the Mun River.

[2] The name Don Mot Daeng meaning "upland of red ant".

Neighboring districts are (from the east clockwise) Tan Sum, Sawang Wirawong, Mueang Ubon Ratchathani, Lao Suea Kok and Trakan Phuet Phon of Ubon Ratchathani Province.

The important water resources are the Mun and Se Bok River.