It is considered to be one of the biggest and most intense rivalries in Gaelic games.
While Tyrone have 13 Ulster titles and Donegal are ranked in sixth position on the roll of honour, they have also enjoyed success in the All-Ireland Senior Hurling Championship, having won 5 championship titles between them to date.
Following the 2013 National Football League meeting of the teams, the then reigning All Stars Footballer of the Year, Donegal's Karl Lacey, was hit by some spit from the mouth of a Tyrone fan.
Lacey was targeted as he left the pitch via the tunnel at Healy Park in Omagh.
President of the Gaelic Athletic Association Liam O'Neill condemned the action against Lacey, "I have always said that any behaviour that makes anyone feel less good about themselves or about being involved in Gaelic games is abhorrent to me.