Biscoe was born in Fort Benning, Georgia, the daughter of Mildred Skillern, a retired Carver High School English teacher.
Her stage credits including Doubt, To Kill A Mockingbird, Waiting To Be Invited, Holiday Heart, Homebody Kabul, Our Town and Fences.
She had recurring roles in the two Oprah Winfrey Network series: drama Greenleaf as Clara Jackson, and prime time soap opera Ambitions as Robin Givens' character's mother.
In 2017, she began starring in the Bounce TV prime time soap opera Saints & Sinners playing villainous Lady Leona Byrd.
In 2024 she starred alongside Garcelle Beauvais, Lela Rochon and Loretta Devine in the Lifetime television movie Terry McMillan Presents: Tempted By Love.