In Parkinson's patients, the death of dopamine-transmitting neurons in this area leads to abnormal nerve-firing patterns that cause motor problems.
[2] DRT increases dopamine in the brain to optimal levels in order to return motor skills, impulsivity, and decision making to normal function.
[3] Although DRT can improve motor skills and decision making in patients with mild to severe Parkinson's disease, an overdose of dopamine is associated with impaired impulsivity (see next section).
DRT medication can increase dopamine in the dorsal frontostriatal circuit to an optimal level, leading to an improvement in task-switching activities and working memory.
[1] Simultaneously, the ventral frontostriatal circuit will experience an overdose of dopamine that will lead to increased impulsive behavior.