The band was founded by Victor Love, Darin Yevonde, Grace Khold and Brian Wolfram.

Currently, their albums are distributed by Trisol in Europe, Subsound in Italy, Metropolis Records in North America, and other small labels including Deathwatch Asia in Japan and other countries.

[3][4] In early 2003, Victor Love, met with friend and designer Grace Khold in Rome, Italy.

The trio soon found Brian Wolfram and all four converged to begin casually writing a demo EP.

Neuromance produced by John Fryer (HIM, Depeche Mode, NIN) was a two-disc bundle Digipack that contained 31 tracks.

[5] Dope Stars' third album and a third EP were both in production for over two years, the longest gap to date for the band to release music.

Dom Smith of Sphere magazine wrote "While ’21st Century Slave’ doesn't make any major adjustments to DSI's tried and tested formula of monstrous cyberpunk, it's certainly their most vibrant and accessible record to date.

Rather than continuing to use a drum machine for albums and live performances, the band is planning to hire a real drummer for their future projects.

[4] On July 7, 2010, the band opened A.Live Rock Festival in Barletta with Extrema and Skid Row as headliners.

On April 12, 2014 Victor Love announced on the band's Facebook page he had started writing material for an upcoming untitled album.

[11] In December 2014, the new album "Terapunk" was announced by Victor Love on the band's Facebook page, with tentative release date for early 2015.

The band was signed by Distortion Productions to distribute physical media of the album for the North American market for March 10, 2015.

Musically, Dope Stars insert the catchy choruses of 1980s pop-metal bands such as Bon Jovi (or, equivalently, 1990s alternative pop bands like Weezer) into the industrial-metal and cyberpunk frameworks of White Zombie, Foetus, Front Line Assembly and KMFDM.

Noting differences in the social standards, Love has felt that he did not want to imitate earlier bands with irony just to sell more records.