On 16 July 1885, the railway line from Dordrecht to Gorinchem was opened.

The neo-Renaissance railway station building is located to the south of the city centre.

These are some of the main destinations directly available from Dordrecht: Rotterdam, The Hague, Leiden, Haarlem, Amsterdam Airport Schiphol, Amsterdam, Roosendaal, Middelburg, Breda, Tilburg, Eindhoven, Venlo, Gorinchem and Geldermalsen.

The stations is served by the following services: As of April 9, 2018 the international service Amsterdam - Brussels will be running on the HSL-Zuid with a stop at Breda and does not call at Dordrecht and Roosendaal anymore.

From the railway station the city bus lines provides services to/from: The routes of the city buses are as follows: Arrives/Continues at Centraal Station as regional bus line 11/12 to/from Centrum and Zwijndrecht.