[5] She started playing football on the streets at the age of ten and was discovered by players who noticed her talent and told her about a project being run by the Nobel Peace Prize nominated[6] Mathare Youth Sports Association (MYSA) with the aim of empowering young people through football.

[5] MYSA was being supported by the Norway Cup, the largest youth football tournament in the world which attracted over 1,000 teams.

[7][10] On 27 September 2009, during her debut during the opening match of the season, she scored a brace to take Bremen to 2–2 draw against Hamburger SV II.

[21] She played her only match for the club on 1 December 2013 when she was substituted in the 84th minute in the 2–1 loss to eventual league winners SC Sand.

[22] In February 2014, she suffered a ruptured achilles tendon which ended her season and her club career in Europe.

[23][4] In 2006, she was a member of the squad that represented Kenya in the first ever Street Football World Cup in 2006 held in Berlin, Germany, leading them to the title.

[5] Nabwire played for the Kenya women's national football team and served as the skipper at one point.

[1][29][30] She served in that role in September 2016 at the 2016 CECAFA Women's Championship where Kenya lost to Tanzania in the finals.

[1][31] She was part of the Harambee Starlets squad that qualified for the 2016 Africa Women Cup of Nations (AWCON) in Cameroon for the first time in the country's history.

Nabwire also worked as a Player-coach specifically as an assistant coach for Matuu FC, which he helped in securing the 2012 Kenyan Women's Premier League.

[20] In March 2013, she left Matuu and worked as a trainer of FKF Girls Premier League club MOYAS Ladies.

[32] In October 2021, she was appointed unto FIFA's technical advisory group on the growth and advancement of women's football.

Her other brother, Anthony Kadudu featured for Tusker FC while her younger sister, Christine Nafula is a footballer who plays for the Kenya women's national team.

[43][3] The organization targets girls in primary and secondary schools within Kenyan communities and empowers them by teaching life skills, decision making and ways to improve their confidence.

[47][48] Nabwire holds a diploma in Tours, Travel, and Cabin Crew and has worked at the Phoenix Safaris, Kenya in the past.