In the 1970s, Ghezzi worked mainly in a duo with American singer Wess, and the couple represented Italy in the 1975 Eurovision Song Contest.

Ghezzi made her first appearance in the San Remo Festival in 1970, performing "Occhi a mandorla", a duet with Rossano, but the song failed to qualify for the final.

The pair subsequently stated that they had been well-treated by their captors; when the kidnappers were apprehended and put on trial, De André would show understanding and sympathy in his testimony.

Piccole donne followed in 1983 and the song "Margherita non lo sa" earned Ghezzi third place at that year's San Remo.

Ghezzi retired from her singing career on medical advice in 1990, having developed a serious problem with her vocal cords, and has since made only infrequent and secondary contributions to recordings by other artists.