He defeated his Communist Party (PCRM) opponent Veaceslav Iordan in the 2007 municipal elections, which resulted in a clear victory for a loose anti-communist coalition in the city of Chișinău (61.17%).

Chirtoacă won reelection as mayor of Chișinău in June 2011, narrowly defeating the candidate from the Communist Party of the Republic of Moldova, Igor Dodon.

The two participated on 28 June 2015 in the second tour, Chirtoacă receiving 53.54% of votes and winning his third consecutive mandate of mayor of Chișinău.

[16] On 12 September 2017, the Chișinău municipal Council decided that on 19 November 2017 a referendum for Chirtoacă's dismissal would be held.

[19] In 2020, Chirtoacă and four other Moldovan politicians founded Mișcarea Politică Unirea, a political party established for the unification of Moldova and Romania.

When this happened, on 31 August 2015, during the holiday celebrating the Romanian language, Chirtoacă asked the ProTV Chișinău journalist Anișoara Loghin to marry him, on the holiday stage in Great National Assembly Square, receiving an affirmative answer.