She wrote more than 2,500 songs, including her most notable, "The Holy Hills of Heaven Call Me", "He Looked Beyond My Fault and Saw My Need", "We Shall Behold Him", and "I Go To the Rock".

As a songwriter, Whitney Houston, Elvis Presley, Carol Channing, Sandi Patty, Barbara Mandrell, Dolly Parton, Vince Gill, Rhonda Vincent, Vestal Goodman, Little Richard, Jerry Lee Lewis, Solomon Burke, and George Jones are among those who have recorded her songs.

Rambo appeared on Pat Robertson's CBN and 700 Club, Paul and Jan Crouch's TBN, Jim and Tammy Faye Bakker's PTL.

Her closest association was with TBN where she had a TV series that ran as their #2 rated show for 6 years, “The Dottie Rambo Magazine”.

Her series featured music, cooking segments, and celebrity guests; Minnie Pearl, Barbara Mandrell, Dottie West, Connie Smith, Lisa Whelchel and many others.

[2] She had the support of her mother and father, and by age ten she was singing and playing country music cover tunes on a local radio program.

Outside of the USO tours she also traveled behind the Iron Curtain, throughout Europe, West Indies, Bahamas, The Holy Land (Israel), and Canada.

After earning as little as $50 a week for years, and often working day jobs to make ends meet, Rambo's fortunes began to improve.

Rambo worked with Billy Graham, Jimmy Swaggart, Oral Roberts, Benny Hinn, Kathryn Kuhlman, John Hagee, Jim Bakker, Tammy Faye Bakker-Messner, Paul and Jan Crouch, Paula White, Reinhard Bonnke, Pat Robertson, T. D. Jakes and others.

[10] Rambo's best-known songs include "We Shall Behold Him", "Holy Spirit Thou Art Welcome (In This Place)", "I Go to the Rock", "Sheltered in the Arms of God", "I Will Glory in the Cross", "He Looked Beyond My Fault", "Tears Will Never Stain the Streets of That City", "For What Earthly Reason", "If That Isn't Love", and "Too Much to Gain to Lose".

She also wrote country music songs recorded by Jimmie Davis, Charlie Louvin, Rhonda Vincent, and Hank Snow, among others.

Rambo's songs have been recorded by a virtual "who's who" in the music world with her biggest songwriting cut being Whitney Houston's version of "I Go to the Rock", which appeared on the motion picture soundtrack for The Preacher's Wife.

In addition, other secular artists have recorded Dottie Rambo compositions, including Solomon Burke, Johnny Cash, Carol Channing, Barbara Fairchild, Larry Gatlin, Crystal Gayle, Vince Gill, Wanda Jackson, George Jones, Alison Krauss, Jerry Lee Lewis, Barbara Mandrell, Bill Monroe, The Oak Ridge Boys, Dolly Parton, Elvis Presley, Little Richard, Jeannie C. Riley, Connie Smith, Hank Snow, Mel Tillis, Rhonda Vincent, Porter Wagoner, and Dottie West.

Numerous Christian/gospel artists have recorded her songs, such as Aaron Jeoffrey, Vanessa Bell Armstrong, The Barrett Sisters, The Blackwood Brothers, The Booth Brothers,The Inspirations, Greater Vision, Commissioned, The Crabb Family, Andrae Crouch, Danniebelle Hall, Jimmie Davis, DC Talk, Jeff and Sheri Easter, The Florida Boys, The Happy Goodmans, Steve Green, Larnelle Harris, Jake Hess, The Hoppers, The Isaacs, Bobby Jones, Ron Kenoly, Doyle Lawson, Mark Lowry, Janet Paschal, Sandi Patty, Karen Peck, The Speer Family, Albertina Walker, Vickie Winans, Karen Wheaton, Jimmy Swaggart, and The Collingsworth Family.

Throughout her career, beginning with the 1960s "Gospel Singing Jubilee", Rambo appeared on numerous television programs on virtually every Christian network as well as the TNN, PAX, and GMT Women's Entertainment channels.

Dottie was part of Christian Television since its conception; appearing on Pat Robertson's CBN, The 700 Club, Paul and Jan Crouch's and TBN, Jim and Tammy Faye Bakker's PTL.

[11] Although partially disabled, Rambo made major television appearances including The 700 Club, and as a regular guest performer on TBN.

[2] The title track, a duet with Dolly Parton, went to the number one spot of the Christian Country Radio Chart, as did its follow-up, "I'm Gonna Leave Here Shoutin'".

The concert was hosted by Barbara Mandrell and included performances by Dolly Parton, Crystal Gayle, Larry Gatlin, The Isaacs, Jessy Dixon, Vestal Goodman, The Speers, The Crabb Family, and Albertina Walker.

In 2010, a tribute album began the recording process, featuring new tracks by artists from various genres of music, such as George Jones, Little Richard, Dolly Parton, Solomon Burke and other legendary performers.

[citation needed] Rambo died on May 11, 2008, as a result of injuries sustained in a bus accident along Interstate 44 just outside Mount Vernon, Missouri.

She had just finished a performance at Calvary Life Church in Granite City, Illinois and was en route to a Mother's Day show in Texas when the 1997 Prévost bus she was traveling in ran off the road, struck a guard rail and hit an embankment.