Douglas (whose family name is sometimes spelled Douglass) was a Scottish-born physician who practiced in Quebec City and was involved in the foundation of the Asile de Beauport.

[8] The Foundation's most recent contribution was towards a $20 million brain imaging centre that was scheduled to open in 2011.

"[11] The institute uses a collaborative and comprehensive approach that includes prevention, treatment, and public intervention.

When an illness manifests itself, sufferers and family members are able to seek specialized treatment and support at the institute, whether through an initial diagnosis at its own emergency room or by referral from a healthcare professional.

[12][13] Douglas Institute helped in creating Maison Claude-Laramée (MCL) in Verdun, in the Montreal area.

MCL is a rehabilitation residence for people who have severe long-lasting psychotic illness and also drug or alcohol abuse or dependence.

Serving nine people at a time, in single rooms, MCL is jointly run by Douglas Institute and the Old Brewery Mission.

[14] The day-to-day operations are managed by staff members of the Old Brewery Mission, which is a Montreal organization serving homeless and poor people.