Downingtown station is a commuter and intercity passenger rail station located in the western suburbs of Philadelphia at West Lancaster Avenue & Stuart Avenue in Downingtown, Pennsylvania.

It is served by most Amtrak Keystone Service and SEPTA Paoli/Thorndale Line trains.

[6] The original Downingtown station was built in the 19th century by the Pennsylvania Railroad, and was destroyed by fire in the early morning of February 24, 1992.

[7] The Pennsylvania Department of Transportation has proposed building a new train station for Downingtown "at about a quarter mile south of Lancaster Avenue on Brandywine Avenue/US 322" starting in 2025.

Downingtown is the westernmost Amtrak station on the Keystone Corridor that is also served by SEPTA's Paoli/Thorndale service.