Doxa Drama is considered one of the most historic and major teams of Greece and was one of the founding members of the Super League, the first tier of Greek football.

Financial and administrative turmoil, however, led to the club being relegated to Greece's amateur division, Delta Ethniki.

In 2008–09, Doxa had a strong year in the Third Division and clinched the Gamma Ethniki North title with two games to spare.

Financial problems continued for Doxa Drama which was never able to return to Alpha Ethniki (Nowadays named Super League).

In February 2019, a group of Russian, and Lithuanian investors based in Delaware purchased 15% of the team (Minority stake).

Each leaf of the clover was written a letter from the GSD (initially the words "Gymnastic Association of Drama").