Doxa Lefkadas competed in the Greek Cup for the first time, in the 2010–11 season.

For the 2016–17 season, the club was granted a wildcard to play in the top-tier level Greek Basket League for the first time.

[1] In 2016, the arena was upgraded, renovated, and more seating was added, in order to meet Greek Basket League standards.

[2] Note: Flags indicate national team eligibility at FIBA-sanctioned events.

Note: Flags indicate national team eligibility at FIBA-sanctioned events.