Dr. Alien is a 1989 American science fiction comedy film starring Judy Landers, Billy Jacoby, and Olivia Barash.

The film's plot centers on an unpopular honors student named Wesley Littlejohn (Billy Jacoby), who becomes involved in an experiment headed by his new, sexy biology teacher, Ms. Xenobia (Judy Landers).

However, this threatens to alienate the girl he really cares about, Leanne (Oliva Barash), and Wesley begins to suspect Xenobia's motives, which may have something to do with the fact that she isn't from Earth.

Nerdy Wesley Littlejohn is a doting son, opposite to his slacker brother Bradford, set to attend a prestigious college.

A stereotypical nerd, bullied at school and relying on Marvin to defuse confrontations, Wesley is also in love with a girl named Leanne, but is too shy to make any kind of approach to her.

That day, in Ackerman's place, a sexy, blond substitute teacher named Ms. Xenobia arrives and informs the class she will be teaching for the time being.

The Sex Mutants play, with support from the Poon Tangs (an all-girl group featuring Ginger Lynn Allen, Linnea Quigley & Laura Albert).

With humans having a similar biology to her species, she and Drax landed on Earth (inadvertently causing Ackerman's demise) and began their experiments with Wesley.

The film ends as Xenobia and Drax head home to their planet, while Wesley continues his new career with the Sex Mutants and his relationship with Leeanne.