The Dr. Archibald Neil Sinclair House on Puʻu Pueo ('Owl Hill') overlooking Mānoa Valley and Diamond Head on the island of Oʻahu was built in 1917 in a Colonial Revival style designed by a leading local architectural firms, Emory and Webb, who also designed the Hawaii Theatre and other fine buildings on the island.

ft. main house is a fine example of the Colonial Revival style as adapted to Hawaiʻi, with extensive verandahs and balconies outside and open spaces inside delineated by columns rather than walls.

ft. maid's quarters and garage accessible from Terrace Drive and an underground bomb shelter (added later) below the front lawn.

He began his medical practice in England before returning to Honolulu, where he served with the United States Public Health Service (1900–1919), as city physician (1901–1909), and as founding director of Leahi Home for tuberculosis patients (1901).

[3] His published research in the fields of bacteriology, immunology, and pulmonary diseases earned him induction into the American College of Physicians and other medical societies.