The Italian release is markedly different from the English-language edition, with more screen time spent on the antics of Franco and Ciccio, and less on Vincent Price and the other cast members.

The film ends with an extended frantic chase through the streets of Rome, and Goldfoot attempting to start World War III between Russia and the United States by dropping a nuclear bomb on Moscow.

American International Pictures agreed to co-finance, provided it could be turned into a sequel to Dr. Goldfoot and the Bikini Machine.

[3] Frankie Avalon was originally intended to reprise his role as Craig Gamble from the first film,[4] but he pulled out due to the impending birth of his third child, and Fabian Forte was cast in his place.

[5] Fabian said Jim Nicholson of AIP came to him and said "Frankie's having another baby and wants to stay at home... and we have this picture shooting in Italy... [he] was so sweet about it".

The American version focused on Goldfoot/Price and was re-edited by Ronald Sinclair, re-scored, and re-written in the dubbing, all without Bava's input.

[15] Samuel Z. Arkoff said that the film's commercial reception was hurt by the refusal of female lead Laura Antonelli to take her clothes off.