The Dr. Issac Elmer Williams House and Office are a pair of buildings in St. Marys, Ohio, United States.

These two buildings, both frame, feature the Queen Anne style common in the early twentieth century.

Its design is similar to that of the house,[2] including an attic gable with imbricated shingles.

As virtually no changes have been made either to the house or to the office — inside or out — they are excellent examples of early twentieth-century Queen Anne architecture, especially because of their location adjacent to each other.

Moreover, these buildings are significant because of their place as a house-and-office combination of a typical early twentieth-century doctor.