Dr. Job Holmes House was listed on the National Register of Historic Places in 1990.

[1] Dr. Job Holmes House is located on the south side of Main Street (United States Route 1), a short way east of the downtown area.

Just to its east stands the Holmes Cottage, also a property of the St. Croix Historical Society.

It is a 2+1⁄2-story wood-frame structure, three bays wide, with a side-gable roof, asymmetrically placed interior brick chimneys, clapboard siding, and a granite foundation.

[2] Dr. Job Holmes arrived in Calais sometime after 1830, and established a medical practice, joining his brother-in-law, Cyrus Hamlin, brother to future United States Vice President Hannibal Hamlin.