It was placed on the Register on June 26, 2008,[2] due to its unique architecture (a mix of Queen Anne and Eastlake), and for being the work of prominent local architect John W. Gaddis.

The Daviess County Interim Report gave the house its highest rating: "Outstanding".

[3] Nelson H. Wilson, born in Jefferson County, Indiana on November 12, 1844, married Matilda M. Campbell in 1889.

[3] The Dr. Nelson Wilson House is a two-story Queen Anne-style house, with a brick foundation, brick and limestone walls, and asphalt roof, built in 1893 by a John W. Gaddis, an architect from nearby Vincennes, Indiana who would later become known for building courthouses, such as those for Clay County, Huntington County, and Putnam County.

This Masonic Cross pattern could be seen as a Maltese Cross motif, save that both Nelson Wilson and John Gaddis were active Freemasons, and the thought of deviating from the Eastlake style to the Masonic Cross style in constructing the side porches is easily explained in one of the two deciding on the style.