Dr. Shrinker (Jay Robinson) is a mad scientist who creates a shrinking ray that can miniaturize anything.

As they make their way to the only house on the island, they meet Dr. Shrinker and his assistant, Hugo (Billy Barty).

The remainder of the series was different efforts by the 'Shrinkies' to return to normal size, while Dr. Shrinker and Hugo want to catch the trio so that they will have physical proof that the ray works for whatever world power wants to buy it.

Dr. Shrinker also implied that he would give the unnamed buyer the Shrinkies as a free bonus.

In 2005, Marty Krofft said that he and his brother would be recording commentary for a DVD release of Dr.