Thomas Wynne (July 20, 1627 – January 16, 1692) was personal physician of William Penn and one of the original settlers of Philadelphia in the Province of Pennsylvania.

Born in Ysceifiog, Wales, where his family dated back seventeen generations to Owain Gwynedd,[1] he accompanied Penn on his original journey to America on the ship Welcome.

[3] While attracted to the study of medicine early on, heavy taxes levied on his family originally made the acquisition of proper learning materials difficult.

His death is noted by the meeting of Radnor Friends Meetinghouse then at Duckett's Farm which in 1950 was located at the West Philadelphia train station not far from his home at Wynnestay.

[11] Among his descendants, through Mary Wynne and Dr. Edward Jones,: John Cadwalader, Lambert Cadwalader, John Dickinson, Sally Wister; through his daughter Rebecca: Charles Dickinson; through his daughter Hannah Joshua Humphreys and Charles Humphreys; through his step daughter Margery Maude Joshua Fisher; great-grandsons, Thomas, and Warner Wynne, through his son Jonathan, son Jonathan all served in the Pennsylvania "Flying Camp" and were taken prisoner by the British at the Battle of Fort Washington and Thomas was held on the prison ships in New York Harbor.