The Dr. William W. Mayo House, located at 118 North Main Street in Le Sueur, Minnesota, United States, is listed on the National Register of Historic Places (NRHP).

William W. Mayo aided pioneers and their families during the Dakota War of 1862 and later moved to Rochester where he became the examining surgeon for the southern Minnesota Civil War draft board.

He and his sons, William and Charles founded the 27-bed Saint Marys Hospital which opened in 1889 following the 1883 Rochester tornado.

[2][3] The next owner of the home was Charlotte Wright Bradley (mother of Elizabeth, who married Carson Nesbit Cosgrove (1853-1936)).

In 1903 Cosgrove presided at the organizational meeting of the Minnesota Valley Canning Company (later renamed Green Giant), becoming a pioneer of canning in the Minnesota River valley.